Publikácie

@article{Pös2023,

title = {Cross-Kingdom Interaction of miRNAs and Gut Microbiota with Non-Invasive Diagnostic and Therapeutic Implications in Colorectal Cancer},

author = {O. Pös and J. Styk and G. Buglyó and M. Zeman and L. Lukyova and K. Bernatova and E. Hrckova Turnova and T. Rendek and Á. Csók and V. Repiska and B. Nagy and T. Szemes},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85164844125&doi=10.3390%2fijms241310520&partnerID=40&md5=7a3be1fd203bc9e0cf04f84a8bbfe4de},

doi = {10.3390/ijms241310520},

issn = {16616596},

year  = {2023},

date = {2023-01-01},

urldate = {2023-01-01},

journal = {International Journal of Molecular Sciences},

volume = {24},

number = {13},

publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},

abstract = {Colorectal cancer (CRC) has one of the highest incidences among all types of malignant diseases, affecting millions of people worldwide. It shows slow progression, making it preventable. However, this is not the case due to shortcomings in its diagnostic and management procedure and a lack of effective non-invasive biomarkers for screening. Here, we discuss CRC-associated microRNAs (miRNAs) and gut microbial species with potential as CRC diagnostic and therapy biomarkers. We provide rich evidence of cross-kingdom miRNA-mediated interactions between the host and gut microbiome. miRNAs have emerged with the ability to shape the composition and dynamics of gut microbiota. Intestinal microbes can uptake miRNAs, which in turn influence microbial growth and provide the ability to regulate the abundance of various microbial species. In the context of CRC, targeting miRNAs could aid in manipulating the balance of the microbiota. Our findings suggest the need for correlation analysis between the composition of the gut microbiome and the miRNA expression profile. © 2023 by the authors.},

keywords = {Gut microbiome, Oncology},

pubstate = {published},

tppubtype = {article}

}

@article{Gromova2023,

title = {The effect of plasma-activated water in a mouse model of inflammatory bowel disease},

author = {B. Gromova and B. Konecna and M. Suchonova and S. Pasztor and P. Celec and L. Tothova and M. Lichvar and J. Budis and J. Radvanszky and D. Rusnakova and T. Szemes and Z. Machala and R. Gardlik},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85160071712&doi=10.1002%2fppap.202300053&partnerID=40&md5=bd251feb6cc3883a722e4cee94b96851},

doi = {10.1002/ppap.202300053},

issn = {16128850},

year  = {2023},

date = {2023-01-01},

urldate = {2023-01-01},

journal = {Plasma Processes and Polymers},

volume = {20},

number = {9},

publisher = {John Wiley and Sons Inc},

abstract = {Inflammatory bowel disease (IBD) is a group of disorders with complex pathogenesis, including oxidative stress and microbial dysbiosis. The aim of this study was to analyze the effect of intracolonic administration of plasma-activated water (PAW) on the oxidative status and gut microbiota diversity in the colon of healthy mice and mice with IBD. Interestingly, PAW increased oxidative stress markers in the colon tissue, and this effect was more pronounced in IBD mice. Our results show that PAW increases microbial diversity in a healthy gut and decreases it in an inflamed gut. We conclude that the effect of PAW is bidirectional and depends on the underlying condition. Our findings do not support the proposed therapeutic potential of PAW in IBD. © 2023 Wiley-VCH GmbH.},

keywords = {Gut microbiome},

pubstate = {published},

tppubtype = {article}

}

@article{Bielik2020,

title = {Gut microbiota diversity in lean athletes is associated with positive energy balance},

author = {V Bielik and I Hric and V BalᎠand A Penesová and S Vávrová and J Grones and B Bokor and J Budiš and M Bohmer and G Minárik and D Augustovičová and K Šoltys},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091307627&doi=10.1159%2f000509833&partnerID=40&md5=4461653fb07e53dc12411cda7d4cb566},

doi = {10.1159/000509833},

issn = {02506807},

year  = {2020},

date = {2020-01-01},

journal = {Annals of Nutrition and Metabolism},

publisher = {S. Karger AG},

abstract = {Introduction: In contrast to obesity, little is known about the human lean phenotype associated with gut microbiota composition. Objective: We aimed to investigate whether the bacterial composition of lean athletes with a positive energy balance differs from the equal-calorie food group. Methods: Twenty-four male participants were included in this cross-sectional study: lean athletes with a positive energy balance (LA, n 12) and control group athletes (CTRLs, n 12). Nutritional data, resting and total energy expenditure, and body composition were determined. DNA was extracted from stool samples and subjected to 16S rRNA gene analysis. Results: We found 7 differentially abundant bacterial taxa between the LA and CTRL groups. Of those, 5 were significantly less abundant and 2 were enriched in the LA group. The following categories significantly associated with the community structure were identified: body fat parameters, BMI, energy intake and expenditure, oxygen consumption, and respiratory exchange ratio. Conclusions: Although we are far from a detailed interpretation of lean human body maintenance, the primary findings of our study suggest that gut microbial composition may be a factor influencing the regulation of weight gain in lean athletes with a positive energy balance. © 2020 Cambridge University Press. All rights reserved.},

keywords = {Bacteria, Gut microbiome, Metagenomics},

pubstate = {published},

tppubtype = {article}

}