Geneton - paternity tests, genetic tests, bioinformatic analyses

Paternity tests

Paternity testing based on DNA analysis has become a routine procedure in providing evidence for the relationship between the biological father and child as well as in case of eliminating any doubt of the child’s father or mother with respect to paternity of that child. DNA paternity testing can confirm or rule out biological relationship practically with a 100 % certainty.

Bioinformatic analyses

Our team has a great experience in biology, statistics and bioinformatics. We are focused mainly on development of methods in clinical diagnostics, analysis of variants, viruses, and transcriptomic analysis, but also provide custom analysis and software development at your service.

Genetic tests

We use modern, next generation sequencing technology (NGS) in our portfolio of genetic tests oriented on identification of causal pathogenic variation. We also offer fragment analysis with capillary electrophoresis in routine practice. Here, you can consult with experts with years of experience in these areas.

Genetic tests

Statistical analyses

Statistics have an important part in our research and make up a significant part of our scientific outcomes. We developed several statistical methods improving accuracy of routine testing. Proposed methods have a significant role in applied biology, particularly in the field of prenatal diagnostics. We provide support and services to make sense of your data according to the best statistical practice.

Scientific activity

The priority of Geneton, s.r.o. is an excellent research and development in the field of state-of-the-art molecular genetics and bioinformatics. It also adapts its personnel policy in line with this priority. Several successfully implemented projects in the past provide sufficient background for project management and sufficient administrative capacity to manage project activities.

18 Feb

Laboratory Information Management System – LIMS

Most of the multi-project research-focused laboratories (like core facilities) try to deal with registration, tracking, integration and monitoring of samples and their analyses. As these data contain personal information, secure storage and access has high priority, also due to new European legislation. To face these challenges, we have developed a web-based Laboratory Information Management System…

17 Feb

SnakeLines: integrated set of computational pipelines for paired-end sequencing reads

Introduction Development of sequencing technologies with massive parallel throughput allowed laboratories around the world to analyze DNA fragments of various organisms. However, actual use of DNA sequencing data is impeded by two main obstructs. Firstly, DNA data processing and interpretation is often difficult for researchers and clinicians with small computational background. Secondly, due to the…

16 Feb

NIPT Test – non-invasive prenatal screening

Geneton developed a non-invasive method for obtaining important information about structural variation of a fetus based on a sample of maternal blood. The method does not pose any risk for the fetus or the mother, therefore represents safe alternative to traditionally used invasive methods.

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27 Aug

Non-invasive prenatal testing (NIPT) by low coverage genomic sequencing: Detection limits of screened chromosomal microdeletions

To study the detection limits of chromosomal microaberrations in non-invasive prenatal testing with aim for five target microdeletion syndromes, including DiGeorge, Prader-Willi/Angelman, 1p36, Cri-Du-Chat, and Wolf-Hirschhorn syndromes. We used known cases of pathogenic deletions from ISCA database to specifically define regions critical for the target syndromes. Our approach to detect microdeletions, from whole genome sequencing data, is based on sample normalization and read counting for individual bins.

7 Sep

Identification of Structural Variation from NGS-Based Non-Invasive Prenatal Testing

We reanalyzed NIPT genomic data from 5018 patients to evaluate CNV aberrations in the Slovak population. Our analysis of autosomal chromosomes identified 225 maternal CNVs (47 deletions; 178 duplications) ranging from 600 to 7820 kbp. In summary, we identified 129 likely benign variants, 13 variants of uncertain significance, and 83 likely pathogenic variants. In this study, we use NIPT as a valuable source of population specific data. Our results suggest the utility of genomic data from commercial CNV analysis test as background for a population study.

1 May

Non-invasive prenatal testing as a valuable source of population specific allelic frequencies

Low-coverage massively parallel genome sequencing for non-invasive prenatal testing (NIPT) of common aneuploidies is one of the most rapidly adopted and relatively low-cost DNA tests. Since aggregation of reads from a large number of samples allows overcoming the problems of extremely low coverage of individual samples, we describe the possible re-use of the data generated during NIPT testing for genome scale population specific frequency determination of small DNA variants, requiring no additional costs except of those for the NIPT test itself.

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Paternity tests

Bioinformatic analyses

Genetic tests

Genetic tests

Statistical analyses

Scientific activity

Laboratory Information Management System – LIMS

SnakeLines: integrated set of computational pipelines for paired-end sequencing reads

NIPT Test – non-invasive prenatal screening

Non-invasive prenatal testing (NIPT) by low coverage genomic sequencing: Detection limits of screened chromosomal microdeletions

Identification of Structural Variation from NGS-Based Non-Invasive Prenatal Testing

Non-invasive prenatal testing as a valuable source of population specific allelic frequencies

RNDr. Tomáš Szemes, PhD.

RNDr. Tatiana Sedláčková, PhD.

Mgr. Jaroslav Budiš, PhD.

RNDr. Ján Radvánszky, PhD.